Non involvement of γ-aminobutyric acid in catechol-induced seizures
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چکیده
منابع مشابه
Acidification and γ-aminobutyric acid independently alter kairomone-induced behaviour
Exposure to high pCO2 or low pH alters sensation and behaviour in many marine animals. We show that crab larvae lose their ability to detect and/or process predator kairomones after exposure to low pH over a time scale relevant to diel pH cycles in coastal environments. Previous work suggests that acidification affects sensation and behaviour through altered neural function, specifically the ac...
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Taurine is essential for the hepatic synthesis of bile salts and, although taurine is synthesized mainly in pericentral hepatocytes, taurine and taurine-conjugated bile acids are abundant in periportal hepatocytes. One possible explanation for this discrepancy is that the active supply of taurine to hepatocytes from the blood stream is a key regulatory factor. The purpose of the present study i...
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Since the cloning of the first γ-aminobutyric acid (GABA) transporter (GAT1; SLC6A1) from rat brain in 1990, more than 50 published studies have provided structure-function information on investigator-designed rat and mouse GAT1 mutants. To date, more than 200 of 599 GAT1 residues have been subjected to mutagenesis experiments by substitution with different amino acids, and the resulting transp...
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Social anxiety disorder (SAD) is the one of the most common anxiety disorders. Despite its high prevalence, the disorder is still considerably undiagnosed and untreated. The disease places a massive burden on patient’s lives, affecting not only their social interactions but also their educational and professional activities, thereby constituting a severe disability. γ-aminobutyric acid (GABA) s...
متن کاملConformation of the neurotransmitter γ-aminobutyric acid in liquid water.
We study the conformation and reorientation dynamics of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) under neutral and acidic conditions using a combination of broadband dielectric relaxation spectroscopy and polarization-resolved femtosecond mid-infrared pump-probe spectroscopy. We find that both zwitterionic and cationic GABA adopt nearly linear conformations in aqueous solution...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1986
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1986.tb10168.x